Some new phenyl pyrimidine derivatives have been synthesized and their characterization was done by IR, 1H NMR and Mass spectral data. The density and sound velocity of some newly synthesized phenyl pyrimidine derivatives have been measured in 1, 4 dioxane solutions over a wide range of concentrations (0.01 to 0.1M) at 298.15 K. From these experimental data, some acoustical parameters have been evaluated and correlated with the concentration. The obtained results give useful information about molecular interactions occurring in solution.