Background: In recent years, cancer incidence has got a rising trend, creating a lot of problems for patients, families, and the community. It is one of the most feared diseases in the community and its development is associated with emotional and psychological fears and problems. That's why it is critical to confront with cancer and the patients’ right confrontation with the disease can produce fewer problems. Therefore, this investigation aimed to deal with the cancer process in cancer patients. Method: Using the grounded theory, the process of dealing with the diagnosis based on the patients and close relatives’ experiences, doctors, and nurses was studied. The study was carried out in the city of Sari in Mazandaran Province in 2013-2014. Unstructured interviews, observations, and field notes were the methods of data collection. Sampling began purposefully and theoretical sampling was gradually followed based on the emergence of codes and classes to achieve the theory evolution. Accordingly, a total of 35 interviews were conducted with 16 patients, 4 family members, 3 doctors, and 3 nurses. Data analysis was performed by using Glaser’s constant comparative method and the process of confronting with cancer was designed and presented according to the findings after the identification of the main concepts. Findings: Data analysis revealed that the participants' main concern when confronting with cancer is " life threatening", while their core strategy is "finding support and hope for surviving". The consequence of this strategy was a relative survival and mobility and the findings demonstrated the participants try to be hopeful for survival and endeavor for the necessary follows-up. The process of confronting with cancer includes the following steps: “Being susceptible to having a serious illness, i.e. cancer”, “Being informed of getting cancer”, “Preparing the patients to get informed of the diagnosis”, “Perceiving a life-threatening danger”, “Finding hope and support for surviving”, and “Having a relative hope for survival / mobility”. Conclusion: The results depicted that patients’ confrontation with cancer is a process consisting of several interwoven phases with a focus on finding support and hope for surviving since promoting hope, life-giving spirit, and supporting the patient in all aspects when diagnosing cancer can provide better outcomes in them and help them to be facing fewer problems in the meantime.