Early maladaptive schemas (EMSs) as key structures in the development of psychopathology. The purpose of current research was studying the role of EMSs as the predictor of psychiatric symptoms including interpersonal sensitivity, psychoticism, paranoia, and hostility in the murderers jailed in Shiraz city. Methods Eighty male jailed murderers were selected at hand sampling method. To gather the data, Demographic Questionnaire, Young Maladaptive Schemas Questionnaire Short Form (YSQ SF) and Symptoms Checklist 90 Revised (SCL 90 R)(questions related to the symptoms of interpersonal sensitivity, psychoticism, paranoia, and hostility) were used. For data analysis, statistical methods of one way variance analysis (ANOVA), Pearson correlation and stepwise multiple variable regression were used. Results Data analysis using stepwise multiple variable regression showed that strongest predictor related to any of interpersonal sensitivity, psychoticism, paranoia, hostility symptoms, listed respectively for these symptoms, were schemas of subjugation, emotional inhibition, entitlement/grandiosity, and emotional inhibition respectively. Conclusions As a whole, it is concluded that the EMSs can predict psychiatric symptoms of interpersonal sensitivity, psychoticism, paranoia, and hostility in the murderers.