Increased oxidative stress in patients of chronic back pain in comparison with healthy control subjects was investigated by measuring the Malondialdehyde (Thiobarbituric Acid reactive substances), Ascorbic acid, Superoxide Dismutase (SOD),Catalase and Glutathione Peroxides (GPX) in erythrocytes .Chronic back pain patients are more prone to oxidative damage than control cases, evident from an increase in Malondialdehyde and decreased Ascorbic acid, Catalase and GPX in erythrocytes, SOD activity-increase was found and probably as an adaptive response to the stress. The role of antioxidants in chronic back pain is clear; these are beneficial to treat this condition.