We examined diseased addicts with prolong history of intravenous drug abuse and we found a number of macroscopic and microscopic morphological pathological changes in kidneys. Their characteristics localization and severity depend on a number of key factors the period of intravenous use of narcotics without complying with the main principles of aseptic treatment the purity of the applied drug and additional substances placed in street narcotics. We studied the morphological (macro and microscopic) changes of kidneys affecting the tubulointerstitial system glomerules glomerular capillary loop and damage of the glomerular capillary basement membrane.