Objective Purpose of the study was to determine the relationship between gender roles and job satisfaction mediated by interpersonal communication motives. Methods It was conducted in the city of Gorontalo, Indonesia, involving 396 respondents. The instruments were adapted from Bem Sex Role Inventory (BSRI), Interpersonal Communication Motives (ICM) and Job Satisfaction Scale (JSS) and analyzed using Macro PROCESS program. Results, Results are showed a negative correlation at -0.0219 between gender roles and job satisfaction. However, there is a significant relationship between gender roles and job satisfaction through a mediator of interpersonal communication motives with indirect effect coefficient at 0.0388. Conclusions It is known that, interpersonal communication motives become the most important mediator variable bwtween gender roles and job satisfaction. The higher gender roles of women workers tend to reduce job satisfaction. However, through the better interpersonal communication motives, the higher gender roles tend to increase their job satisfaction.