Keratoconus is a relatively common bilateral, non-inflammatory corneal ectasia. Keratoconus has a multifactorial etiology with multiple genetic and environmental component contributing to the disease pathophysiology. In the keratoconic cornea, a possible genetic predisposition to increased sensitivity, to apoptotic mediators by keratocytes has also been hypothesized. Advances in Computerized Topographic Diagnostic Technique for KC including formefrusteKeratoconus, enables higher accuracy in delineating abnormal to normal, and helps studying genetic linkages for populations.