Bhagandara1 is one of the most common anorectal disease in field of Shalya tantra. It has been included in Astha Mahagada2 by Acharya Sushruta, after surgery high recurrence rate is matter of great concern. An appropriate answer is a unique specialized parasurgical procedure Kshar Sutra Therapy3 which is well accepted and without any complication, In the present research“Effect of Papaya-Tankan Kshar Sutra in the management of Bhagandara” has been evaluated. Total 40 patients were taken in one group and treated with Papaya-Tankan Kshar Sutra out of which 100% were Cured Completely without any complications. Result was observed on the basis of subjective (Pain, Burning sensation, Itching, Discharge and Inflammation) and objective parameters (Unit Cutting Time i.e. U.C.T.) and analysed statistically. The best response was seen in reduction of Burning Sensation and Pain after ligation by Papaya-Tankan Kshar Sutra. U.C.T. was also not high but in desired limits. Moreover, thearpy did not caused any hindrance in their daily routine work during period of management. No complications were observed in this clinical study.